OYO BUTURI
Vol.88
No.4
2019
4
20194884262
OYO BUTURI Vol.88 No.4 (2019)
Our Research

Development of SiN nanopore sensors for direct DNA sequencing

Itaru YANAGI1, Rena AKAHORI1, Yusuke GOTO1, Kenichi TAKEDA1

This paper summarizes the latest developments regarding solid-state nanopores achieved in our laboratory. To realize DNA sequencing with solid-state nanopores, many issues must be resolved. In particular, from the standpoint of device fabrication and DNA manipulation, we believe that there are three key issues: (1) stable fabrication of a small nanopore with a diameter on the same order as that of DNA, (2) fabricating an ultrathin membrane, and (3) decreasing the DNA translocation speed through a nanopore. We addressed these three issues, and successfully observed sequence-specific currents through a nanopore while DNA remained in the nanopore.

  • 1 Hitachi Ltd, Research and Development Group, Biosystems Research Dept
OYO BUTURI Vol.88 No.4 p.262 (2019)