Clarification of the formation mechanism of anisotropic bone microstructure based on materials science, and the development of bone substitute materials and devices
Takayoshi NAKANO1, Takuya ISHIMOTO1
Our research group is ultimately trying to establish a new academic field, “(bio)materials science based on anisotropy” focusing on living bone and the related biomaterials. The measurement of bone mineral density that has been conventionally used for bone diagnosis is insufficient to evaluate the function and/or strength in various bones such as pathological and regenerated bones. Because the apatite crystal in bones has an anisotropic hexagonal crystal structure, the orientation of the apatite c-axis in the bone matrix should be considered as a bone quality parameter that governs the bone mechanical function. In this manuscript, our latest knowledge of the anisotropic bone microstructure, its formation mechanism, and the development of artificial biomaterials for inducement of anisotropic bone microstructures are introduced.
- 1 Biomaterials & Structural Materials Design Area, Division of Materials & Manufacturing Science, Graduate School of Engineering, Osaka University