OYO BUTURI
Vol.87
No.9
2018
9
20189879670
OYO BUTURI Vol.87 No.9 (2018)
Our Research

Applications of a hybrid photodetector (HPD) to biological fluorescence microscopes and wide-field fluorescence detection of mobile single biomolecules with high temporal resolution using an HPD

Hiroaki YOKOTA1, Atsuhito FUKASAWA2

Fluorescence microscopy is indispensable to life science research because it allows us to image live biomolecules in real time. In particular, single-molecule fluorescence microscopy is useful. It uncovers the dynamic features of individual biomolecules such as movement and structural change. In this paper, we introduce the hybrid photodetector (HPD), a low light detector with a light-receiving surface, high temporal resolution, and high sensitivity. Then, we compare the HPD with other low light detectors and briefly explain how the HPD is applied to biological fluorescence microscopes. Finally, we present wide-field fluorescence detection of mobile single biomolecules with high temporal resolution using an HPD.

  • 1 The Graduate School for the Creation of New Photonics Industries
  • 2 Hamamatsu Photonics K.K.
OYO BUTURI Vol.87 No.9 p.670 (2018)